Stem cell research for breast cancer

Furthermore, being resistant to conventional therapies, the CSCs are predicted to be main culprits leading to tumor relapse. Reis-Filho JS : Next-generation sequencing. In a larger cohort of more than patients with primary breast cancer, Morimoto et al. Oncogene 32 : - , Proc Natl Acad Sci : - , The presence of ATP-binding cassette transporters which confer resistance to chemotherapeutic agents highly expressed in a subpopulation of CSCs with these markers led to such assumption 21 , J Trans Med 9 : ,
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The Ludwig Center for Cancer Stem Cell Research and Medicine

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Implications of Different Cancer Stem Cell Phenotypes in Breast Cancer

This phenotype was recently demonstrated to have high tumorigenic ability in breast cancer cell lines and also a highly metastatic propensity, being resistant to standard cancer therapies Cancer Res 74 : - , Thus, a practical example would be the application of NGS in isolated BCSCs defined by different combinations of BCSC markers from primary tumors and their corresponding metastases in order to determine which gene is more frequently mutated hotspot mutations in each subpopulation of BCSCs. Clin Cancer Res 15 : - , Beachy has long been studying how cancer is related to the repair mechanisms of normal cells. Nat Med 14 : - , The Ludwig Center for Cancer Stem Cell Research and Medicine at Stanford is dedicated to investigating cancer and its treatment from the perspective of stem cell biology and medicine.
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Breast cancer stem cell - Wikipedia

Both pre-clinical and clinical studies have shown a correlation between BCSCs and metastasis. Translational Research. The view that cancer is driven by cancer stem cells CSCs has the capacity to change the whole field of cancer research and lead to entirely new, targeted cancer therapies that cure cancer without the toxicities that are common in most current treatments. Keysar SB , Jimeno J : More than markers: biological significance of cancer stem cell-defining molecules. The rationally designed multifunctional nanodrug will offer new possibilities of penetration into tumour niches and open new horizons for cancer treatment. Stem Cells 29 : 32 - 45 ,
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Chin Med J : - , In addition, CD49f cooperates with receptor tyrosine kinases to communicate, bidirectionally, between the cell and the extracellular matrix ECM. Current therapeutic strategies include targeting CSC signaling pathways that play critical roles in self-renewal and defense. Clin Cancer Res 19 : - , Interesting studies have been published with promising results in targeting these integrins such as through the use of short hairpin RNAs or micro-RNAs
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